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参与左右交替的神经网络的双模式运行
Adolfo E Talpalar1, Julien Bouvier, Lotta Borgius
1The Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm S-17177, Sweden.
Nature
|July 2, 2013
概括
运动速度由脊髓神经元网络控制. 在小鼠中切除特定的V0神经元组揭示了不同的步态模式,显示了这些神经元如何调节不同速度的左右协调.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 脊髓研究研究 脊髓研究
背景情况:
- 运动依赖于协调的肌肉激活和脊髓神经网络.
- 步行模式中的左右协调与运动速度有关,但其神经基础尚不清楚.
- 委托神经元参与左右协调,但它们的具体作用和因果关系仍然难以捉摸.
研究的目的:
- 为了研究将左右协调与运动速度联系起来的神经机制.
- 确定特定 commissural 神经元群体 (V0) 在步态控制中的因果作用.
- 阐明中央机动控制系统的模块化组织.
主要方法:
- 利用切割性小鼠遗传学用于针对性废除V0神经元群体.
- 在选择性V0神经元切除后,检查了各种运动频率的步态模式.
- 区分了激发性和抑制性V0神经元在协调运动中的作用.
主要成果:
- 所有V0神经元的切除导致四足人以各种速度跳跃.
- 选择性切除抑制性V0神经元,在低速时损害左右交替,但在高速时诱导左右交替.
- 准刺激性V0神经元导致中/高速度跳跃,低速度交替跳跃.
结论:
- 运动的中央控制表现出模块化组织,具有不同的V0神经元子组,以不同的速度控制左右交替.
- 两个分子上不同的V0神经元组可能会影响物种特定的协调和步态演变.
- 这项研究提供了对塑造步态模式和其进化多样化的神经约束的见解.
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