深层的皮质层是直接由丘脑激活的
Christine M Constantinople1, Randy M Bruno
1Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA.
概括
感官信息通过直接的甲状腺皮层 (TC) 突触到达皮层到深层 (L5/6),而不仅仅是通过4层 (L4). 这揭示了大脑中的并行处理流.
科学领域:
- 神经科学是一个神经科学.
- 皮层电路中的皮层电路.
- 感官处理 感官处理
背景情况:
- 甲状腺皮层 (TC) 投影是传递感官信息到皮层的主要途径.
- 人们普遍认为,感官信息从第4层 (L4) 传播到其他皮质层 (L2/3,L5/6).
研究的目的:
- 为了研究从 thalamus 到深层皮质层 (L5/6) 的直接突触输入.
- 要确定第四层 (L4) 是否是传送感官信息到L5/6神经元的强制性中继.
主要方法:
- 在老鼠体内电生理学记录.
- 来自体和L5/6神经元的配对记录.
- 第4层 (L4) 的药理性失活.
主要成果:
- 许多L5/6神经元显示直接的TC突触输入与与L4反应相似的延迟.
- 直接TC突触的实质性融合到各种亚粒神经元上,特别是在L5B.
- L4的非激活不会影响传感唤起的突触输入到L5/6神经元.
结论:
- 第4层 (L4) 不是传感性皮质活动的强制性分发枢纽.
- 泰拉马斯激活了单独的,平行的皮质处理流,直接针对L4和L5/6神经元.
- 这挑战了在皮层内信息流的传统层次观.
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