在接受血管造影的患者中,对外周动脉附带循环的直接定量评估
Tobias Traupe1, Jana Ortmann, Michael Stoller
1Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland.
Circulation
|July 3, 2013
概括
在外周动脉疾病患者的量化附带流量指数 (CFIp) 显示,适当的休息附带功能可以在短暂的闭塞期间预防缺血. 然而,演习显示出供需不匹配或盗窃现象.
科学领域:
- 血管医学 血管医学
- 血液动力学 血液动力学
- 周围动脉疾病 周围动脉疾病
背景情况:
- 周围动脉疾病 (PAD) 缺乏量化下肢附带动脉功能的方法.
- 改善附带功能是PAD患者的一个关键策略.
研究的目的:
- 开发和验证一种定量方法,用于评估PAD患者下肢附带动脉功能.
- 在诱导性闭塞和运动期间,与缺血症状相关联附带功能.
主要方法:
- 使用联合压力/多普勒线来测量表面大腿动脉中压力衍生的附带流量指数 (CFIp).
- 在休息和运动条件下测量远端闭塞压力和脚的氧和度 (Sao2).
- 在表面的股骨动脉进行气球阻塞5-10分钟.
主要成果:
- 休息时CFIp在闭塞期间增加,与Sao2下降相反相关,与无疼痛持续时间相反相关.
- 炼导致CFIp大幅下降,表明供需不匹配.
- 89%的患者在10分钟的闭塞期间经历了缺血症状,而CFIp预测了无痛持续时间.
结论:
- 休息的CFIp定量评估了附带功能,预测了闭塞期间无症状的持续时间.
- 在CFIp的演练诱导下降突出了在需求增加期间抵押品供应的限制.
- 该研究确立了CFIp作为评估PAD中抵押品功能的有价值指标.
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