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Updated: May 10, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

不同的α-synuclein菌株在神经元中差异地促进tau的包容性

Jing L Guo1, Dustin J Covell, Joshua P Daniels

  • 1Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Cell
|July 6, 2013
PubMed
概括

独特的α-synuclein (α-synuclein) 纤维的菌株可以交叉种子tau聚合,影响神经退行性疾病,如帕金森氏症. 这些发现揭示了蛋白质菌株多样性是疾病异质性的基础.

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