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哺乳动物大脑发育期间的全球表观基因组重构

Ryan Lister1,2, Eran A Mukamel3, Joseph R Nery1

  • 1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|July 6, 2013
PubMed
概括

在大脑发育过程中,DNA甲基化模式发生显著变化,非CG甲基化 (mCH) 在人类神经元中占主导地位. 这项研究绘制了整个生命周期中的这些动态变化,揭示了对学习和记忆的洞察力.

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