从人类中分离出来的H7N9 A型流感病毒的特征
Tokiko Watanabe1, Maki Kiso, Satoshi Fukuyama
1ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Nature
|July 12, 2013
概括
新型禽流感A ((H7N9) 病毒在动物模型中表现出高致病性,并且可以感染人类呼吸道. 中的有限传染性表明潜在的流行病风险,需要进一步调查.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 禽流感A型病毒 (AIVs) 由于潜在的人类适应和传播而构成流行病威胁.
- 最近在中国的人类感染禽类A ((H7N9) 是由于高死亡率和缺乏人类免疫力而令人担忧的.
研究的目的:
- 描述早期人类A(H7N9) 隔离物的致病性和传染性.
- 评估A(H7N9) 病毒的流行病潜力.
主要方法:
- 在小鼠,和非人类灵长类动物中进行感染研究.
- 在呼吸道组织中进行复制测试.
- 病毒传播研究 ().
- 糖甘受体结合试验. 糖甘受体结合试验.
- 抗病毒敏感性测试.
主要成果:
- 人类A(H7N9) 隔离物 (安/1,上海/1) 在小鼠中比对照病毒更具有病原性.
- 在非人类灵长类动物的上下呼吸道中发生了有效的复制.
- 安/1显示,小黑猩猩的呼吸液滴传播有限.
- A(H7N9) 病毒与人类类型的受体结合,可能有助于传播.
结论:
- A(H7N9) 病毒在哺乳动物模型中表现出显著的复制,并与人类受体结合.
- 这些发现表明,A(H7N9) 病毒具有流行病潜力.
- 进一步的监测和研究是有必要的,以监测和应对潜在的A(H7N9) 威胁.
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