通过在新陈代谢系统中脱离进化创新的潜在能力
1Institute of Evolutionary Biology and Environmental Sciences, Building Y27, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Nature
|July 16, 2013
概括
许多进化创新,如代谢特征,可能会作为非适应性突变产生的. 这项研究揭示了代谢网络中的适应往往提供了多个意想不到的功能,这表明了比以前认为的更多的非适应性起源.
科学领域:
- 进化生物学是进化生物学.
- 代谢网络是一种代谢网络.
- 生物化学 生物化学
背景情况:
- 进化创新可以以非适应性的方式出现,作为外接 (其他特征的副产品).
- 例如,飞行前的羽毛和源自酶的透镜晶体.
- 适应性特征的非适应性起源的频率至关重要,但很难研究.
研究的目的:
- 调查代谢系统中非适应性起源的流行情况.
- 分析代谢网络从单一碳来源合成生物质的能力.
- 为了探索进化生物学中的新陈代谢中脱离的含义.
主要方法:
- 能够维持生命的随机代谢网络的计算抽样.
- 对各种碳来源的网络可行性的分析.
- 利用新的计算方法来模拟生化反应.
主要成果:
- 在一个碳来源上可行的代谢网络通常在许多其他来源上表现出可行性.
- 代谢系统的适应通常会导致多个潜在的脱离.
- 例如,在葡萄糖上的可行性可以赋予多达44个额外的碳来源的可行性.
结论:
- 代谢系统具有具有非适应性起源的进化创新的潜在潜力.
- 相当多的代谢特征可能有非适应性起源.
- 在新陈代谢中区分适应性和非适应性特征是一个挑战.
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