光选择性的DNA头旋转开关
Raanan Carmieli1, Arun K Thazhathveetil, Frederick D Lewis
1Department of Chemistry and Argonne-Northwestern Solar Energy Research (ANSER) Center, Northwestern University, Evanston, Illinois 60208-3113, USA. r-carmielli@northwestern.edu
Journal of the American Chemical Society
|July 17, 2013
概括
研究人员开发了用 antraquinone (Aq) 和 perylenediimide (PDI) 进行分子旋转切换的DNA发针. 波长选择性光刺激控制单基或三基基离子对的形成,展示了一种基于DNA的新型旋转开关.
科学领域:
- 分子生物学分子生物学
- 摄影化学的使用
- 量子化学是一种量子化学.
背景情况:
- DNA纳米结构提供了对分子相互作用的精确控制.
- antraquinone (Aq) 和 perylenediimide (PDI) 是具有明显电子性质的光活性分子.
- 激素离子对 (RP) 的形成和旋转动力学在光化学和分子电子学中至关重要.
研究的目的:
- 用Aq和PDI功能化的DNA针头进行合成和特征化.
- 为了研究这些DNA针头的波长依赖光刺激.
- 为了证明DNA针头作为分子旋转开关的潜力.
主要方法:
- 合成含有Aq和PDI末组和基因替代物的DNA发针.
- 选择性的PDI (532 nm) 和Aq (355 nm) 的光刺激.
- 时间分辨率电子磁共振 (EPR) 光谱分析激素离子对的自旋状态.
主要成果:
- 选择性光激发产生了不同的单元 (PDI) 和三元 (Aq) 基离子对 (RP).
- 激进对系统间交叉导致混合自旋状态与相反的EPR光谱相.
- 在没有显著的能量转移的情况下,对RP旋转状态的波长选择性控制.
结论:
- 设计的DNA针头可以作为高效的分子旋转开关.
- 波长选择性光刺激允许精确控制单片/三片RP形成.
- 这项工作为基于DNA的分子电子学和自旋电子学开辟了道路.
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