西尼罗河病毒:文献综述
Lyle R Petersen1, Aaron C Brault, Roger S Nasci
1Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Fort Collins, Colorado 80521, USA. lxp2@cdc.gov
JAMA
|July 18, 2013
概括
西尼罗河病毒仍然是美国的重大公共卫生威胁,导致广泛的疾病和神经侵入性疾病. 预防侧重于综合蚊子管理,以控制这种持续的树木病毒挑战.
科学领域:
- 关节动物传播的病毒性疾病
- 公共卫生监督是对公共卫生的监督.
- 传染病流行病学 传染病流行病学
背景情况:
- 西尼罗病毒 (WNV) 于1999年在北美出现,迅速引起了主要的树状病毒神经侵入性疾病爆发.
- 现在它在整个连接的美国已经流行,造成了持续的健康问题.
研究的目的:
- 提供对西尼罗河病毒的全面审查.
- 强调其生态学,病毒学,流行病学,临床表现,诊断和预防策略在北美.
主要方法:
- 在PubMed电子数据库的文献搜索,截至2013年2月5日.
- 来自疾病控制和预防中心 (CDC) 的美国国家监测数据的分析.
主要成果:
- 自1999年以来,已报告超过16000例神经侵入性病例和1500例死亡;估计有超过78万例疾病.
- 神经侵入性疾病影响感染个体的<1%,但死亡率约为10%;会导致长期的软弱.
- 诊断依赖于检测IgM抗体;治疗是支持性的,没有获得许可的人类疫苗. 综合性害虫管理是预防的关键.
结论:
- 西尼罗病毒是北美可怕和持续的临床和公共卫生挑战.
- 持续的警和综合管理策略对于控制WNV传播和影响至关重要.
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