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Updated: May 9, 2026

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在新型原始体中,Ptpn11的删除会通过诱导刺信号传递引起甲状腺瘤

Wentian Yang1, Jianguo Wang, Douglas C Moore

  • 1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA. wyang@lifespan.org

Nature
|July 19, 2013
PubMed
概括

氨酸酸酶SHP2 (编码为PTPN11) 作为软骨中的瘤抑制剂,与其在其他细胞中的作用不同. 在特定的原始细胞中,SHP2的丧失会通过破坏FGFR/MEK/ERK信号传递而导致甲状腺瘤.

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