框:两个纳米长的合成受体的相互依赖的结合方式
Michal Juríček1, Jonathan C Barnes, Edward J Dale
1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Journal of the American Chemical Society
|July 20, 2013
概括
一个新的合成受体,Ex(2)Box(4+),通过独特的电子特性来识别广泛的客人. 这种四离子旋与多种分子形成稳定的复合体,展示了广泛的分子识别能力.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 旋是多功能分子宿主,具有可调节的识别特性.
- 扩展viologen单元为分子相互作用提供独特的电子特性.
- 设计具有广泛客体兼容性的受体仍然是超分子化学的一个关键挑战.
研究的目的:
- 合成和描述一种新型的四离子旋风,Ex(2)Box(4+),其中包含双烯桥接扩展型生物体单元.
- 调查Ex(2)Box(4+) 对各种客分子的广泛分子识别能力.
- 通过实验和计算方法阐明Ex(2)Box(4+) 的结合机制和亲缘关系.
主要方法:
- 合成一种基于二烯的循环,其功能与扩展的viologen单位相结合.
- 形成和表征二进制和三进制的包含综合体与各种客人.
- 光谱分析 (UV-vis,NMR) 和单晶X射线衍射以研究结合相互作用.
- 密度函数理论 (DFT) 计算以探测绑定能量和模式.
主要成果:
- (Ex(2)Box(4+) 采用类似盒子的几何形状 (~2纳米长) 并识别了广泛的客体,包括多环芳和电子贫乏芳.
- 该受体形成稳定的1:1复合体与含有二氧化纳乙烯单元的聚乙烯宏循环.
- 旋风扇末端和中间的不同电子特性使得选择性捐赠者-接受者和宿主-客人相互作用成为可能.
- 由于协同结合模式,观察到某些复合物的高稳定常数.
结论:
- Ex(2)Box(4+) 在分子识别方面表现出了显著的多功能性,可以容纳不同大小,形状和电子性质的客人.
- 旋风机组件的独特电子特性促进了多式联接.
- 这项研究提供了对开发先进合成受体的设计原则的见解,这些受体在宿主-客化学中具有广泛的适用性.
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