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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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在p53的转录激活过程中,SET1和p300通过结合的基因素修饰作用,协同作用

Zhanyun Tang1, Wei-Yi Chen, Miho Shimada

  • 1Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

Cell
|July 23, 2013
PubMed
概括

SET1复合体 (SET1C) 和p300通过修改基因素H3的乙化和三甲基化来加强基因转录. 这种机制对于p53介导的基因调节至关重要,特别是在DNA受损后.

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