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相关概念视频

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...

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相关实验视频

Updated: May 8, 2026

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
10:16

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

Published on: July 13, 2015

一个表观遗传陷稳定了单一的嗅觉受体表达.

David B Lyons1, William E Allen, Tracie Goh

  • 1Tetrad Program, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|July 23, 2013
PubMed
概括
此摘要是机器生成的。

希斯脱甲基酶LSD1和腺基酶3 (Adcy3) 控制嗅觉受体 (OR) 的表达. Adcy3降低了LSD1的调节,稳定了嗅觉神经元 (OSN) 中的单个OR表达.

更多相关视频

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

相关实验视频

Last Updated: May 8, 2026

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
10:16

Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

Published on: July 13, 2015

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 控制哺乳动物嗅觉受体 (OR) 基因表达的分子机制在很大程度上是未知的.
  • 了解嗅觉感官神经元 (OSN) 如何实现单数OR表达,对于嗅觉系统的功能至关重要.

研究的目的:

  • 阐明调节嗅觉受体 (OR) 表达的启动和稳定的分子机制.
  • 确定参与OSN中OR选择的表观遗传调节的关键信号通路.

主要方法:

  • 在OR表达中研究了组织素脱甲基酶LSD1和腺基环酶3 (Adcy3) 的作用.
  • 在OSNs中分析了LSD1和Adcy3的短暂表达模式和功能相互作用.
  • 检查了涉及LSD1,Adcy3和OSN分化的信号级联.

主要成果:

  • 启动OR转录需要LSD1的短暂表达,而其下调对于稳定的OR表达至关重要.
  • Adcy3的OR-依赖表达作为传感器和反发射器,调节LSD1下调.
  • Adcy3促进OSN分化,锁定所选OR的表观遗传状态,确保单一表达.

结论:

  • 一个涉及LSD1和Adcy3的新型三节点信号级联调节OR表达.
  • 这种级联通过表观遗传锁定选择的等位基因并防止进一步的OR激活来稳定单一的OR表达.
  • 这些发现为嗅觉系统中基因表达和神经元分化的表观遗传控制提供了关键的见解.