亚临床左心室功能障碍和沉默的脑血管疾病:心血管异常和脑损伤 (CABL) 研究
Cesare Russo1, Zhezhen Jin, Shunichi Homma
1Department of Medicine, Columbia University, New York, NY 10032, USA.
Circulation
|August 2, 2013
概括
全球纵向菌株 (GLS) 在一般人群中检测亚临床大脑疾病,包括静音脑梗塞. 这种心脏测量提供了超出传统左心室喷射率 (LVEF) 评估的脑血管风险的见解.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 亚临床的脑血管病变,如静音脑梗塞 (SBI) 和白质强度过高,与中风和认知衰退有关.
- 左心室喷射分数 (LVEF) 预测心力衰竭中风,但其与一般人群中亚临床大脑疾病的关系尚不清楚.
- 左心室全球纵向应变 (GLS) 可以识别早期的心脏功能障碍,即使是正常的LVEF.
研究的目的:
- 在社区基队伍中调查LVEF,GLS和亚临床大脑疾病之间的关联.
- 为了确定GLS是否与LVEF相比,提供了关于脑血管风险的额外信息.
主要方法:
- 心声学 (2D和斑点跟踪) 在439名没有先前中风或心脏病的参与者中评估了LVEF和GLS.
- 大脑MRI评估SBI和白质超强度.
- 多变量分析检查了心脏测量和脑损伤之间的关系.
主要成果:
- 较低的GLS,但不是LVEF,与SBI的存在有显著的关联.
- 减少GLS独立预测的SBI (或1.18每单位下降,P<0.01).
- 较低的GLS与较大的白质超强度体积相关,而LVEF没有.
结论:
- 低GLS在一般社区队列中独立与亚临床大脑疾病相关.
- GLS提供了关于超出LVEF的大脑血管风险的有价值信息.
- GLS可以作为一种新的生物标志物,用于识别患脑血管事件风险的个体.
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