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在活细胞中纳米级温度测量

G Kucsko¹, P C Maurer, N Y Yao

¹Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

|August 2, 2013

概括

研究人员使用钻石开发了一种新的纳米级温度计.

科学领域:

物理物理学物理
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

精确的纳米尺度温度测量对于各种科学领域至关重要.
现有的方法缺乏生物系统所需的灵敏度和集成能力.

研究的目的:

开发一种高度灵敏的纳米级温度计.
为了证明其在生物系统中的应用,用于温度映射和控制.

主要方法:

在钻石中的空 (NV) 中心中利用电子旋转的连贯操纵.
使用钻石纳米晶体 (纳米钻石) 进行局部温度传感.
在人类胚胎纤维细胞内集成的纳米钻石和金纳米粒子.

主要成果:

达到低至1.8mK (9mK Hz−1/2) 的温度灵敏度.
在200纳米尺度上成功测量了局部热环境.
在活细胞中展示了细胞下温度梯度控制和映射.

结论:

基于NV中心的温度计为纳米级温度计提供了前所未有的灵敏度.
这种技术可以在生物系统中实现精确的温度控制和绘制地图.
为基因表达,疾病治疗和集成电路分析的应用开辟了新的途径.

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