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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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一个分子内 (3 + 1) 人类端粒G-四重复的溶液结构,与端粒胺衍生物结合

Wan Jun Chung1, Brahim Heddi, Masayuki Tera

  • 1School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore.

Journal of the American Chemical Society
|August 6, 2013
PubMed
概括

研究人员揭示了第一个高分辨率结构的人类端粒G-四重复合体复杂与端粒胺衍生物. 这一发现推动了针对G-四重复结构的新型抗癌药物的开发.

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