PQM-1补充了DAF-16,作为DAF-2中介发育和寿命的关键转录调节剂

Ronald G Tepper1, Jasmine Ashraf2, Rachel Kaletsky2

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Cell
|August 6, 2013
PubMed
概括

降低胰岛素/IGF-1类信号传导 (IIS) 通过改变基因表达来延长寿命. 这项研究确定PQM-1是控制发育基因的关键因素,揭示了在调节压力和衰老方面与DAF-16的对抗关系.

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