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Updated: May 5, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

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调节性T细胞的稳定性和功能是由神经皮林-1-赛马福林-4a轴维持的

Greg M Delgoffe1, Seng-Ryong Woo, Meghan E Turnis

  • 1Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nature
|August 6, 2013
PubMed
概括

调节性T细胞 (Treg细胞) 对于免疫平衡至关重要,但阻碍了抗瘤免疫力. 塞马4a-Nrp1通路维持Treg稳定性,提供治疗点,以增强抗瘤反应而不会引起自身免疫.

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