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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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在具有优化的细胞中选择性检测和抑制活性caspase-3

Chris J Vickers1, Gonzalo E González-Páez, Dennis W Wolan

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|August 7, 2013
PubMed
概括

研究人员开发了新的探针,可以选择性地检测和抑制caspase-3. 这一突破可以更好地了解caspase-3的作用.

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相关概念视频

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.