在之间,H7N9流感A病毒的空气传播有限
Mathilde Richard1, Eefje J A Schrauwen, Miranda de Graaf
1Department of Viroscience, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Nature
|August 9, 2013
概括
禽流感A ((H7N9) 病毒在人类和鸟类菌株之间的中间体,在鱼中显示出有限的空气传播能力. 需要进一步的研究来了解哺乳动物之间有效的空气传播的决定因素.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 野生水禽是流感A病毒的储存库,具有动物传播的潜力.
- 禽流感A ((H7N9) 在中国引起了严重的人类疾病,引发了对其传播的担忧.
- 空气传播是有效的人对人流感传播的主要途径.
研究的目的:
- 在哺乳动物模型中研究A/Anhui/1/2013 A(H7N9) 病毒在空气中传播的可能性.
- 了解影响禽流感病毒在空中传播的病毒决定因素.
主要方法:
- 使用A/Anhui/1/2013 A(H7N9) 病毒在中进行实验性传播研究.
- 在鱼通过过程中选择的病毒遗传变异的分析.
主要成果:
- 甲型 (H7N9) 病毒在中表现出有限的空气传播能力,位于典型的人类和禽流感病毒之间.
- 通过过程中选择了具有改变受体结合,融合pH和热稳定的病毒遗传变异.
- 这些选定的变异可能表明传播能力降低.
结论:
- 甲型 (H7N9) 病毒具有人类适应的决定因素,但在中具有有限的空气传播能力.
- 了解控制禽流感在空中有效传播的因素至关重要.
- 这项研究强调了对具有流行病潜力的禽流感病毒的持续监测和研究的需要.
相关概念视频
Viral Recombination
25.8K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.8K
Viral Mutations
40.9K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.9K
Influenza
51
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
51


