在单胞胎和双胞胎双胞胎中,先天性心脏缺陷的患病率增加
Anne Maria Herskind1, Dorthe Almind Pedersen, Kaare Christensen
1Department of Pediatrics, Hans Christian Andersen Children's Hospital at Odense University Hospital, Odense (A.M.H.); The Danish Twin Registry, University of Southern Denmark, Odense (D.A.P., K.C.); and Departments of Clinical Genetics and Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C (K.C.), Denmark.
Circulation
|August 10, 2013
概括
在双胞胎中,先天性心脏缺陷比单胞胎更常见. 这种增加的风险适用于所有双胞胎,而不仅仅是单双胞胎,强调需要仔细进行心脏评估.
科学领域:
- 周围生理学 周围生理学
- 心脏病学 心脏病学
- 双胞胎研究 双胞胎研究
背景情况:
- 之前的研究表明,单心双胞胎与双心双胞胎和单心双胞胎相比,单心双胞胎的先天性心脏缺陷 (CHD) 率更高.
- 病例系列报告还表明双胞胎妊娠与心血管疾病发病率增加之间存在潜在联系.
研究的目的:
- 为了调查与单双相比,双胞胎的大量队列中先天性心脏缺陷的发生情况.
- 为了确定双胞胎中心血管疾病风险的增加是否特定于单双胞胎.
主要方法:
- 使用了丹麦双胞胎登记和统计局的丹麦登记 (包括国家医疗出生登记和丹麦国家患者登记) 来获取1977-2001年的数据.
- 分析了41,525名双胞胎和74,473名单身双胞胎的数据,追踪到2006年.
- 进行了敏感性分析,仅包括住院患者或手术治疗病例.
主要成果:
- 双胞胎与单胞胎相比,患心血管疾病的风险增加了63%,分别为1.4%和0.87%.
- 特定的心血管疾病,如专利的动脉管和大动脉缩,在双胞胎中发生的频率是双胞胎的三倍以上.
- 在双胞胎 (双胞胎) 中观察到心脏病发生率增加,这表明风险不仅限于单胞胎妊娠.
结论:
- 在双胞胎中,先天性心脏缺陷明显比单胞胎更常见.
- 双胞胎中心血管疾病的风险增加是独立于胆管性.
- 建议对所有双胞胎进行子宫内监测和产后心脏评估,不论其胆管状或状.
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