通过静脉注射免疫接种非复制性杂虫虫疫苗来预防疟疾
Robert A Seder1, Lee-Jah Chang, Mary E Enama
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov
Science (New York, N.Y.)
|August 10, 2013
概括
一种新的Plasmodium falciparum (Pf) sporozoite (SPZ) 静脉注射 (IV) 疫苗在成年人中显示出安全性和有效性. 多剂量PfSPZ疫苗显示出对疟疾感染的显著保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 实现一致的,高水平的疫苗诱导人类疟疾防护一直是一个重大挑战.
- 蚊虫咬伤注射Plasmodium falciparum (Pf) 杂虫 (SPZ) 是迄今为止唯一的一种方法,始终诱导高水平的保护.
研究的目的:
- 评估无菌净化,冷保存的pfspz疫苗的安全性,耐受性和有效性,该疫苗是静脉注射 (IV).
- 为了确定免疫反应的剂量依赖性和接种疫苗后对疟疾的保护.
主要方法:
- 40名成年人接受了四到六次PfSPZ疫苗的静脉注射.
- 试验对象接受了受控的人类疟疾感染,以评估疫苗的疗效.
- 测量了PfSPZ特异性抗体和T细胞反应.
主要成果:
- 在所有成年受试者中,PfSPZ疫苗是安全的,并且耐受良好.
- 观察到疫苗的有效性,在五剂组中0/6个受试者和4剂组中3/9个受试者在感染后患上疟疾,相比之下5/6个对照组 (P = 0.015和P = 0.028).
- 针对pfspz特异性抗体和T细胞的反应是剂量依赖的.
结论:
- 静脉注射PfSPZ疫苗是安全的,并诱导剂量依赖的免疫反应.
- 这种IV疫苗可以达到剂量依赖的免疫值,以获得高水平的抗疟疾保护.
- 该PfSPZ疫苗符合监管标准,并显示出预防疟疾的前景.
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