分子拥挤稳定了固有无序的无状态和重复在毒素 (RTX) 蛋白质的折叠结合状态

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Ana-Cristina Sotomayor-Pérez1, Orso Subrini, Audrey Hessel

  • 1Unité de Biochimie des Interactions Macromoléculaires, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.

Journal of the American Chemical Society
|August 15, 2013
PubMed
概括

大分子拥挤增强了RTX蛋白的结合和稳定性,如RC(L). 这种在无序 (apo) 和折叠 (holo) 状态中观察到的效应表明,拥挤会影响蛋白质的输出和细胞内的功能.

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