RNA-155

Stephane Heymans1, Maarten F Corsten, Wouter Verhesen

  • 1Center for Heart Failure Research, Department of Cardiology (S.H., M.F.C., W.V., P.C., R.E.W.v.L., K.C., T.P., M.H., M.v.B., A.-P.P., B.S.), Department of Molecular Genetics (L.S., M.P.J.d.W.), Department of Pathology (E.W., E.L.), Department of Pharmacology (B.J.J.), Department of Cardiology (L.J.d.W.), and Department of Internal Medicine (K.W.), Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands (S.H.); Center for Molecular and Cardiovascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium (S.H., P.C., A.-P.P.); Department of Medical Biochemistry (L.S., E.L., M.P.J.d.W.) and Heart Failure Research Center (E.E.C., Y.M.P.), Academic Medical Center, Amsterdam, the Netherlands; Cluster of Excellence Cell Networks, Department of Infectious Diseases/Virology, Virus Host Interactions, Heidelberg University, Heidelberg, Germany (D.G., N.S.); Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Cambridge, UK (E.V.); Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany (T.T.); Medical Microbiology, Maastricht University, Maastricht, the Netherlands (F.S.); King's BHF Centre, King's College London, London UK (X.Y., M.M.); Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany (E.L.); and Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy (S.Z., M.G.).

Circulation
|August 20, 2013
PubMed
概括

巨细胞中的microRNA-155驱动心脏炎症和高血压中的过度缩小. 在巨细胞中抑制microRNA-155为高血压心脏病和心脏衰竭提供了潜在的治疗方法.