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微生物殖民影响了肠道内膜自身的早期B系发展

Duane R Wesemann1, Andrew J Portuguese, Robin M Meyers

  • 1Program in Cellular and Molecular Medicine and Department of Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. dwesemann@research.bwh.harvard.edu

Nature
|August 23, 2013
PubMed
概括

B细胞的发育发生在小鼠的肠膜内,而不仅仅是骨髓. 这种与肠道相关的B细胞发育,涉及V(D) J重组和受体编辑,受到肠道微生物的影响,并形成抗体谱.

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