循环基因Bmal1调节Ly6C(hi) 炎症单细胞的白天振荡
Khoa D Nguyen1, Sarah J Fentress, Yifu Qiu
1Cardiovascular Research Institute, University of California, San Francisco, CA 94158-9001, USA.
Science (New York, N.Y.)
|August 24, 2013
概括
昼夜基因Bmal1调节炎症单细胞中的昼间节律,控制它们向感染部位的移动. 破坏Bmal1会损害免疫反应,并促进炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 分子生物学分子生物学
背景情况:
- 循环时钟调节生理节奏,预测环境变化.
- 分子时钟存在于天生的免疫细胞中,但其在单细胞平衡中的作用尚不清楚.
研究的目的:
- 调查昼夜节律在单细胞平衡和贩运中的作用.
- 确定昼夜基因Bmal1对单细胞功能和炎症的影响.
主要方法:
- 对Ly6C(hi) 炎症单细胞的日间变化的分析.
- 调查骨髓细胞特异性Bmal1删除对单细胞贩运和化学激素表达的影响.
- 评估Bmal1表达变化的小鼠对Listeria monocytogenes感染的保护.
主要成果:
- Ly6C(hi) 炎症单细胞在向炎症部位的流通中表现出白天的变化.
- 昼夜基因Bmal1的抑制活动调节了这种节律性贩运.
- 骨髓细胞特异性的Bmal1丧失会破坏单细胞循环,并增加对炎症病理的易感性.
结论:
- BMAL1在控制Ly6C单细胞数量的昼间节律方面发挥着至关重要的作用.
- 单细胞的循环调节对于有效的免疫反应和预防炎症疾病至关重要.
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