聚 ((iohexol) 纳米颗粒作为在体内X射线计算机断层扫描成像中的对比剂
Qian Yin1, Felix Y Yap, Lichen Yin
1Department of Materials Science and Engineering, §Department of Veterinary Clinical Medicine, and ⊥Department of Bioengineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Journal of the American Chemical Society
|August 31, 2013
概括
新的生物相容的多 (iohexol) 纳米粒子提供了增强的X射线计算机断层扫描 (CT) 成像. 这些纳米粒子提供长时间的瘤保留和显著改善的对比度,使得在长时间内更准确的诊断,而不需要重复注射.
科学领域:
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
- 材料科学 材料科学 材料科学
背景情况:
- 对于X射线计算机断层扫描 (CT) 的传统小分子对比剂在瘤保留和诊断准确性方面存在局限性.
- 需要先进的对比剂,提供长时间的可见性和更好的成像质量.
研究的目的:
- 开发和评估可生物相容的多 (iohexol) 纳米粒子作为用于体内X射线CT成像的新型对比剂.
- 评估这些纳米粒子在瘤床中的保留时间和CT对比度增强.
主要方法:
- 通过对iohexol和hexamethylene diisocyanate进行交叉链接来合成聚iohexol纳米粒子.
- 交联聚合物与mPEG-多聚化物共同沉,形成纳米粒子.
- 进行了体内CT成像以评估纳米粒子的性能.
主要成果:
- 与传统药物相比,Poly ((iohexol) 纳米颗粒在瘤床内保持时间显著延长.
- 注射后4小时,CT对比度增加了36倍.
- 在广泛的时间框架内实现了更好的诊断准确性.
结论:
- 生物相容的多 (iohexol) 纳米粒子代表了CT对比剂的有前途的进步.
- 这些纳米粒子增强了瘤可视化,并减少了对多次管理的需求.
- 开发的纳米粒子有可能提高癌症诊断和监测的准确性.
相关概念视频
X-ray Imaging
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...
Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Radiological Investigation I: X-ray and CT
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...
Computed Tomography
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...


