相关实验视频

Updated: May 8, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

功能不对称的RAF激酶二元体的阿洛斯特激活

Jiancheng Hu1, Edward C Stites2, Haiyang Yu2

  • 1Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA.

Cell
|September 3, 2013
PubMed
概括

RAF 激酶控制细胞生长,它们的激活涉及一个不对称的二元体,其中一个激酶激活另一个. 这个过程需要N-终端酸化,可以被改造成一个构成性活跃的突变物.

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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