多分析仪对成性非处方药 (OTC) 的感知
Tsuyoshi Minami1, Nina A Esipenko, Ali Akdeniz
1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University , Bowling Green, Ohio 43403, United States.
Journal of the American Chemical Society
|September 5, 2013
概括
这项研究引入了一种新的光传感器阵列,使用黄素[n]uril受体来检测与药物相关的氨基. 传感器阵列为分析药物混合物和尿液样本提供高吞吐量和灵敏度.
科学领域:
- 超分子化学 超分子化学
- 分析化学是一种分析化学.
- 化学传感器是一种化学传感器.
背景情况:
- 黄瓜[n]urils是具有独特结合性质的宏环宿主.
- 开发用于药物检测的选择性和敏感传感器至关重要.
- 现有的方法往往缺乏高吞吐量,需要大量的样本准备.
研究的目的:
- 开发和评估一种超分子传感器阵列,用于检测与药物相关的氨基.
- 在定性和定量分析中评估阵列的性能.
- 在复杂矩阵中展示高通量药物监测的潜力.
主要方法:
- 使用两个光库库尔比特[n]uril型受体 (探头1和探头2) 制造一个传感器阵列.
- 度定位实验用于研究探头-分析物相互作用.
- 在溶液和人体尿液中检测氨基的定性和定量测试.
- 将传感器阵列的性能与现有的最先进方法进行比较.
主要成果:
- 传感器阵列表现出用于检测与药物相关的氨基的互补选择性.
- 个别探针显示了可变的,交叉反应的,取决于分析物的光变化.
- 在定性和定量测试中,表现出了卓越的识别能力.
- 在混合物和人体尿液中的分析物的定量分析取得了成功.
- 传感器阵列在吞吐量和灵敏度方面超越了当前的方法,消除了对固相提取 (SPE) 的需求.
结论:
- 开发的超分子传感器阵列有效地检测和量化与药物相关的氨基酸.
- 黄瓜[n]uril型受体显示为先进的传感应用具有前途.
- 这种方法可以实现简单,高通量药物分析,可能会彻底改变药物监测.
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