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埃克泰纳西丁的总合成 743

Fumiki Kawagishi1, Tatsuya Toma, Tomohiko Inui

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|September 5, 2013
PubMed
概括

通过使用l-胺酸,实现了新型合成ecteinascidin 743. 该研究详细介绍了一个简洁的B环构造策略,改善了对这种复杂分子的访问.

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Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...