高密度脂蛋白胆固醇,大小,颗粒数和强效他类药物治疗后的残留血管风险
Samia Mora1, Robert J Glynn, Paul M Ridker
1Center for Cardiovascular Disease Prevention, Division of Preventive Medicine (S.M., R.J.G., P.MR.) and Division of Cardiovascular Medicine (S.M., P.MR.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Biostatistics, Harvard School of Public Health, Boston, MA (R.J.G.).
Circulation
|September 5, 2013
概括
在接受他类药物治疗的患者中,高密度脂蛋白颗粒数 (HDL-P) 可能比HDL胆固醇 (HDL-C) 更好地预测心血管疾病风险. 这一发现表明,HDL-P可能是未来疗法更有效的点.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 药理学 药理学 是一个学科.
背景情况:
- 化学测量高密度脂蛋白胆固醇 (HDL-C) 可能不会准确地反映HDL的临床疗效.
- 在他类药物治疗期间,其他高密度胆固醇测量方法,如高密度胆固醇颗粒数 (HDL-P) 在残留心血管风险中的作用在很大程度上是未知的.
研究的目的:
- 为了调查HDL颗粒数 (HDL-P) 或HDL大小是否比HDL胆固醇 (HDL-C) 和阿波利波蛋白A-I (apoA-I) 更好地预测残留心血管疾病 (CVD) 风险.
- 评估罗斯瓦斯塔丁对各种高血压水平参数的影响.
主要方法:
- 来自"预防中使用他类药物的理由:评估罗斯瓦斯塔丁的干预试验" (JUPITER) 研究的数据分析.
- 使用核磁共振光谱学测量HDL大小和HDL-P.
- 在10886名参与者接受罗斯瓦斯塔丁治疗前后的HDL-C和阿波利波蛋白AI (apoA-I) 的化学测定.
主要成果:
- HDL-P与apoA-I的相关性比HDL-C更强.
- 罗斯瓦斯塔丁显著降低了LDL-C,并增加了HDL-C,apoA-I,HDL-P和HDL大小.
- 在治疗期间,HDL-P在接受罗斯瓦斯塔丁治疗的患者中显示出与心血管疾病风险的显著反向关联,即使对HDL-C进行调整后,这种关联仍然显著.
结论:
- 在接受强效他类药物治疗的患者中,高密度胆固醇颗粒数 (HDL-P) 与高密度胆固醇-C和apoA-I相比,可以作为残留心血管风险的优异标记.
- 这些发现对开发针对高密度胆固醇代谢和功能的新疗法有影响.
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