用基酸安装的聚合物微粒用于向固体瘤中的化表位
Stephanie Deshayes1, Horacio Cabral, Takehiko Ishii
1Department of Materials Engineering, ‡Department of Bioengineering, §Division of Tissue Engineering, and ∥Center for Disease Biology and Integrative Medicine, Graduate School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Journal of the American Chemical Society
|September 14, 2013
概括
基酸 (PBA) 向纳米载体显示出癌症治疗的前景. 这些新型细胞有效地将酸向瘤细胞,增强药物输送并减少体内黑色素瘤的生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 纳米载体的干介导向增强了化疗的疗效.
- 化甘氨酸在瘤细胞上过度表达,使其成为一个可行的点.
- 甲酸 (PBA) 选择性地与酸 (SA) 结合.
研究的目的:
- 开发PBA安装的状纳米载体,用于向癌细胞上的化表位.
- 为了将抗癌药物oxaliplatin纳入这些纳米载体.
- 在体外和体内评估PBA安装纳米载体的疗效.
主要方法:
- 制造含有氧化的PBA安装的状纳米载体.
- 在pH 6.5.5下使用光光谱学评估SA的PBA-micelle亲和力.
- 对B16F10黑色素瘤细胞的细胞吸收和体外细胞毒性的评估.
- 在体内研究中使用了正位素和肺转移黑色素瘤模型.
主要成果:
- 装有PBA的菌体显示出对SA的高度亲和力,即使是在内pH条件下.
- 增强细胞识别和癌细胞吸收PBA-菌体.
- 改善了体外细胞毒性对B16F10小鼠黑色素瘤细胞.
- 在 орто托普和肺转移模型中,瘤生长率显著降低.
结论:
- 装有PBA的状纳米载体有效地向瘤细胞上的化甘氨酸.
- 这些纳米载体在体外和体内都显示出增强的抗癌活性.
- 具有PBA功能的纳米载体具有提高化疗中瘤向的潜力.
相关概念视频
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

