在细胞形状中解码信息
Padmini Rangamani1, Azi Lipshtat, Evren U Azeloglu
1Department of Pharmacology and Systems Therapeutics and Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell
|September 17, 2013
概括
细胞形状通过改变血曲率来影响健康,从而影响细胞信号传递. 长长的细胞集中激活的受体,放大信号,并以它们的形状存储信息.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 系统生物学 系统生物学
背景情况:
- 细胞形状是细胞健康和功能的关键指标.
- 细胞解码形状相关信息的机制在很大程度上是未知的.
- 血曲率是将形状转化为细胞信号的潜在媒介.
研究的目的:
- 为了研究细胞形状的延长如何影响等离子体膜信号传递.
- 为了探索等离子体膜曲率变化解码形状信息的假设.
- 要确定细胞形状是否作为一种信息存储形式.
主要方法:
- 利用分析数学方法和数值模拟来模拟细胞形状对信号传输的影响.
- 分析了激活受体与血曲线相关的分布.
- 通过操纵细胞异常度进行实验验证.
主要成果:
- 数学分析显示,活性受体在较高曲率区域的短暂积累,细胞异心率增加.
- 由于反应-扩散失衡,这种受体分布遵循周期性模式 (马修函数).
- 数字模拟表明,这些受体微域放大下游信号,在生长因子受体通路中增加激活的细胞质Src和核MAPK1,2水平.
结论:
- 细胞形状,特别是离心率,直接影响了血信号传递动态.
- 在曲的膜区域的激活受体积累放大了细胞内信号通路.
- 实验验证证了细胞形状作为可检索信息存储的位置.
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