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相关概念视频

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Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
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Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
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Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
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The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
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在细胞形状中解码信息.

Padmini Rangamani1, Azi Lipshtat, Evren U Azeloglu

  • 1Department of Pharmacology and Systems Therapeutics and Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cell
|September 17, 2013
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概括
此摘要是机器生成的。

细胞形状通过改变血曲率来影响健康,从而影响细胞信号传递. 长长的细胞集中激活的受体,放大信号,并以它们的形状存储信息.

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 系统生物学 系统生物学

背景情况:

  • 细胞形状是细胞健康和功能的关键指标.
  • 细胞解码形状相关信息的机制在很大程度上是未知的.
  • 血曲率是将形状转化为细胞信号的潜在媒介.

研究的目的:

  • 为了研究细胞形状的延长如何影响等离子体膜信号传递.
  • 为了探索等离子体膜曲率变化解码形状信息的假设.
  • 要确定细胞形状是否作为一种信息存储形式.

主要方法:

  • 利用分析数学方法和数值模拟来模拟细胞形状对信号传输的影响.
  • 分析了激活受体与血曲线相关的分布.
  • 通过操纵细胞异常度进行实验验证.

主要成果:

  • 数学分析显示,活性受体在较高曲率区域的短暂积累,细胞异心率增加.
  • 由于反应-扩散失衡,这种受体分布遵循周期性模式 (马修函数).
  • 数字模拟表明,这些受体微域放大下游信号,在生长因子受体通路中增加激活的细胞质Src和核MAPK1,2水平.

结论:

  • 细胞形状,特别是离心率,直接影响了血信号传递动态.
  • 在曲的膜区域的激活受体积累放大了细胞内信号通路.
  • 实验验证证了细胞形状作为可检索信息存储的位置.