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胚胎中的斑马图案:条纹的激活或条纹间的抑制?

S B Carroll1

  • 1Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.

Cell
|January 12, 1990
PubMed
概括

胚胎发育中的基因调节包括激活和抑制元素. 特定的基因相互作用控制了条纹的形成,这对胚胎发育至关重要.

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.