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人类转录启动复合体的基因组组织

Bryan J Venters1, B Franklin Pugh

  • 1Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

Nature
|September 20, 2013
PubMed
概括

研究人员使用ChIP-exo绘制了人类基因组转录启动部位的地图,揭示了大多数非编码RNA来自促进体. 关键的启动因子,TATA盒结合蛋白 (TBP) 和转录因子IIB (TFIIB),与RNA聚合酶II (Pol II) 相互作用,在核心促进元素中.

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