在患有肺动脉高血压的患者中,右心室静脉功能障碍
Silvia Rain1, M Louis Handoko, Pia Trip
1Departments of Pulmonology (S.R., P.T., C.T.-J.G., N.W., P.E.P., A.V.-N., F.S.d.M.), Physiology (S.R., M.L.H., N.W., G.J.S., W.J.P., C.A.C.O., J.v.d.V., F.S.d.M.), Cardiology (M.L.H.), and Medical Physics (J.T.M.), VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, the Netherlands; Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.); INSERM UMR 999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.); AP-HP, Hôpital de Bicêtre, Service de Pneumologie, DHU Thorax Innovation, Le Kremlin-Bicêtre, France (M.H.); Heart & Lung Transplant Unit, St. Vincent's Hospital and Victor Chang Cardiac Research Institute, Sydney, Australia (P.M.); Muscle Research Unit, Institute for Biomedical Research, University of Sydney, Sydney, Australia (C.d.R.); Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson (C.S., C.G.H., H.L.G.); and ICIN-The Netherlands Heart Institute, Utrecht, the Netherlands (J.v.d.V.).
在肺动脉高血压 (PAH) 中,右心室透静硬度升高,由心肌细胞内的原蛋白增加和硬化瘤驱动. 这一发现澄清了PAH进展的机制.
科学领域:
- 心血管生理学心血管生理学
- 肺高血压研究 肺高血压研究
- 心脏机械学 心脏机械学
背景情况:
- 在肺动脉高血压 (PAH) 中右心室 (RV) 透静硬度的作用仍然不完全理解.
- 研究RV透静硬度对于理解PAH病理生理学至关重要.
研究的目的:
- 为了确定在患有PAH的患者中RV透静硬度的存在和机制.
- 为了将RV透静硬度与PAH中的疾病严重程度相关联.
主要方法:
- 在21名PAH患者和7名对照人群中进行了单击RV压力-体积分析.
- RV组织分析包括缩和纤维化组织学,以及隔离心肌细胞机制.
- 在RV组织中评估了蒂异形成分和酸化.
主要成果:
- 与对照组相比,RV透静硬度 (β) 在PAH患者中显著增加 (0.050 ± 0.005对比0.029 ± 0.003;P<0.05) 并与疾病严重程度相关.
- 患有PAH的患者表现出增加的RV心肌细胞大小和纤维化.
- 从PAH患者中分离的RV心肌细胞显示了显著增加的被动张力,表明了体硬化,降低了酸化.
结论:
- 在PAH中,RV透静硬度显著升高.
- 增加的原沉积和RV心肌细胞肉瘤的内在硬化有助于PAH中的RV透静硬度.
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