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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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相关实验视频

Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

绘制人类表观基因组的地图.

Chloe M Rivera1, Bing Ren

  • 1Ludwig Institute for Cancer Research, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA; The Biomedical Sciences Graduate Program, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA.

Cell
|October 1, 2013
PubMed
概括
此摘要是机器生成的。

表观基因组图揭示了细胞特异信息,有助于理解基因调节和发育. 本综述涵盖了表观基因组映射工具及其在DNA甲基化和染色质结构分析中的应用.

更多相关视频

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

相关实验视频

Last Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

科学领域:

  • 基因组学和表观基因组学
  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 表观基因组与基因组不同,它包含关键的细胞特异信息.
  • 高通量技术的进步使得广泛的人类表观基因组绘制成为可能.

研究的目的:

  • 审查当前的表观基因组映射工具包.
  • 讨论表观基因组图在理解基因调节和发育方面的有用性.
  • 突出表观遗传学领域的进展和挑战.

主要方法:

  • 专注于DNA甲基化测绘技术.
  • 对染色质修饰状态的分析.
  • 染色质结构的表征.

主要成果:

  • 表观基因组图在识别人类基因调节序列方面起着重要作用.
  • 这些地图有助于划分复杂的发展计划.
  • 目前的工具为跨细胞类型的表观遗传变异提供了洞察力.

结论:

  • 表观基因组测绘是一个快速发展的领域,对生物学和医学有重大影响.
  • 需要进一步的研究来克服现有的挑战,并充分利用表观基因组数据.
  • 表观基因组图为破译细胞身份和功能提供了强大的资源.