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Updated: May 7, 2026

A Method to Study de novo Formation of Chromatin Domains
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赖于希拉的素H3.3沉积促进了在ES细胞的发育位点的PRC2招募

Laura A Banaszynski1, Duancheng Wen2, Scott Dewell3

  • 1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York, 10065 USA.

Cell
|October 1, 2013
PubMed
概括

基因组变异H3.3对于聚合体抑制复合体2 (PRC2) 在小鼠胚胎干细胞 (ESC) 中建立基因沉默标记 (H3K27me3) 是必不可少的. H3.3 枯竭减少了 PRC2 结合和 Hira 陪伴物相互作用,影响了分化.

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