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十-十一转位-2 (TET2) 是光滑肌肉细胞可塑性的主调节者

Renjing Liu1, Yu Jin, Wai Ho Tang

  • 1Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (R.L., Y.J., W.T., X.Z., J.H., J.Y., K.A.M.), Department of Surgery (Cardiac Surgery) (L.Q., G.T.), and Department of Pharmacology (K.A.M.), Yale University, New Haven, CT.

Circulation
|October 1, 2013
PubMed
概括

十-十一转位-2 (TET2) 是平滑肌肉细胞 (SMC) 分化的主表观遗传调节器. 失去TET2和5-基甲基细胞因子 (5-hmC) 与血管损伤和疾病相关,而TET2的恢复减轻了增生症.

关键词:
细胞分化的细胞分化.在表观基因组学上,表观基因组学.调节基因表达 调节基因表达过度增生症 过度增生症肌肉,光滑的 肌肉,光滑的

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