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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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Published on: November 22, 2014

在AdoMet-依赖的甲基转移酶中,碳-氧-结合的保护和功能重要性

Scott Horowitz1, Lynnette M A Dirk, Joseph D Yesselman

  • 1Howard Hughes Medical Institute , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|October 8, 2013
PubMed
概括

非传统的CH···O键稳定了S-adenosylmethionine (AdoMet) 的结合和甲基组对齐在甲基转移酶中. 这一发现揭示了AdoMet依赖甲基化的共同进化机制,跨越了多种类型的酶.

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