皮质细胞衍生的亚托皮性皮肤炎细胞因子TSLP激活神经元以诱导
Sarah R Wilson1, Lydia Thé, Lyn M Batia
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Cell
|October 8, 2013
概括
研究人员发现,上皮细胞释放甲状腺 stromal 淋巴蛋白 (TSLP) 直接激活感官神经元,导致皮炎 (AD) 的. 这种TSLP释放是由皮肤细胞中的ORAI1/NFAT路径调节的.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 皮肤病学 皮肤病学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病,影响10%的人口.
- 严重的AD可以导致喘和过敏性鼻炎,这种进展被称为"atopic march".
- 胸膜 stromal lymphopoietin (TSLP) 信号传递与AD病变发生和亚托皮性病程有关.
研究的目的:
- 为了研究表皮细胞衍生的TSLP在中介性皮肤炎中的作用.
- 确定调节TSLP从皮肤上皮细胞释放的分子机制.
- 阐明TSLP在促进行为中的神经元点.
主要方法:
- 研究了从角质细胞释放的TSLP.
- 利用成像研究了角质细胞中的ORAI1/NFAT通路.
- 研究了TSLP对感觉神经元,特别是TRPA1阳性神经元的影响.
- 评估了对TSLP刺激的反应行为.
主要成果:
- 表皮细胞通过TSLP与皮肤感官神经元通信,诱导.
- ORAI1/NFAT信号通路对于TSLP从角质细胞释放至关重要.
- TSLP直接激活TRPA1阳性感官神经元的一个子集,触发.
- 这一途径有助于皮肤和呼吸道的炎症反应.
结论:
- 通过TSLP识别了一种新的皮炎中的信号传递机制,涉及通过TSLP进行表皮神经元通信.
- ORAI1/NFAT通路调节TSLP的释放,将信号与连接起来.
- 准TSLP或其信号通路可能为亚托皮炎和亚托皮病征程提供治疗策略.
相关概念视频
Sensory Functions of the Skin
9.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.1K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
1.8K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K
T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
T Cell Types and Functions
3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Drug Toxicity: Allergic Reactions
209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Inflammatory Bowel Disease III: Crohn's Disease
35
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
35


