多发性硬化症的细胞疗法:一个不断发展的概念,对其他神经退行性疾病有影响
Claire M Rice1, Kevin Kemp, Alastair Wilkins
1University of Bristol Institute of Clinical Neurosciences, Burden MS Stem Cell Laboratories and BrAMS Unit, Frenchay Hospital, Bristol, UK.
Lancet (London, England)
|October 8, 2013
概括
干细胞治疗对多发性硬化症 (MS) 具有前景,因为它提供神经保护和免疫调节,而不仅仅是简单的细胞替代. 这种方法也可能有利于其他神经疾病.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 是年轻人神经障碍的主要原因.
- 多发性硬化症的病理包括髓损失,寡细胞损伤以及整个中枢神经系统 (CNS) 的轴突/神经元损伤.
- 目前的多发性硬化症治疗方法不足,这种疾病仍然无法治愈.
研究的目的:
- 评估用于MS的干细胞治疗的潜力.
- 为了探索超越直接细胞替代的先进干细胞特性.
- 确定MS和其他神经退行性疾病的新治疗途径.
主要方法:
- 综述了解多发性硬化病理和干细胞生物学方面的最新进展.
- 对MS中自发髓修复机制的分析.
- 研究干细胞的特性,如免疫调节,神经保护和与居住干细胞的相互作用.
主要成果:
- 在多发性硬化症中,自发性髓修复比以前认为的更广泛.
- 轴突和神经元损失,而不仅仅是髓损伤,与残疾进展相关.
- 干细胞具有免疫调节和神经保护能力,对于MS治疗至关重要.
结论:
- 多发性硬化症的干细胞治疗必须解决复杂的病理问题,而不仅仅是取代寡细胞.
- 干细胞通过免疫调节,神经保护和与内源性修复机制的相互作用提供了多方面的治疗潜力.
- 基于干细胞的策略对治疗多发性硬化和其他神经系统疾病具有前景.
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