维生素D补充剂对骨矿物质密度的影响:系统性审查和元分析
Ian R Reid1, Mark J Bolland2, Andrew Grey1
1Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Department of Endocrinology, Auckland District Health Board, Auckland, New Zealand.
Lancet (London, England)
|October 15, 2013
概括
维生素D补充剂对大腿部的骨矿物质密度有很小的益处,但其他部位没有. 不建议在没有缺陷风险的成年人中广泛使用骨质疏松症预防.
科学领域:
- 骨健康 骨健康 骨健康
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 最近对没有的维生素D补充剂的分析没有证明骨折预防.
- 老年人经常使用维生素D补充剂,尽管没有确的证据.
- 骨矿物质密度 (BMD) 是评估干预措施影响的敏感标志物.
研究的目的:
- 为了研究维生素D补充剂对成年人骨矿物密度 (BMD) 的影响.
- 为了确定单独的维生素D是否可以影响骨硬化,而不管摄入量.
- 巩固随机试验中关于维生素D对BMD影响的证据.
主要方法:
- 在2012年7月8日之前,我们对Web of Science,Embase和Cochrane图书馆进行了系统的搜索.
- 包括随机试验比较维生素D (D2或D3) 补充与安慰剂或没有干预的成年人没有代谢性骨病.
- 数据使用随机效应元分析进行了聚合,以骨硬度的百分比变化为主要终点.
主要成果:
- 包括23项研究,包括4082名参与者 (92%为女性,平均年龄为59岁).
- 分析显示,小,统计学上显著的好处在腿部部的BMD (0.8%的增长),与相当大的异质性.
- 在其他部位,包括整个部,没有观察到对BMD的显著影响,并注意到对积极结果的偏差.
结论:
- 仅仅维生素D补充剂对大腿部骨质瘤的益处很小,但总体而言没有.
- 研究结果表明,对于一般成人群体的骨质疏松症预防,不支持常规维生素D补充剂.
- 对有记录的维生素D缺乏症患者进行有针对性的补充可能更合适.
更多相关视频
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
8.8K
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.3K
相关概念视频
01:25Role of Vitamins in Maintaining Bone Health
5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
01:29Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
01:31Essential Minerals for Bone Health
6.3K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.3K
01:23Role of Skin in Vitamin D Synthesis
8.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.2K
01:40Bone Remodeling
34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
01:21Skeleton and Calcium Homeostasis
8.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.5K