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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.8K
Anchoring Junctions01:03

Anchoring Junctions

4.3K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.3K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
Adherens Junctions01:24

Adherens Junctions

5.9K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.9K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
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相关实验视频

Updated: May 7, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

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一个细胞外粘附分子复杂的模式树突分支和形态发生.

Xintong Dong1, Oliver W Liu, Audrey S Howell

  • 1Howard Hughes Medical Institute, Department of Biology, Stanford University, 385 Serra Mall, Stanford, CA 94305, USA.

Cell
|October 15, 2013
PubMed
概括

科学家们确定了一种由三分子组成的复合物,该复合物指导神经细胞树突的生长. 这一发现揭示了细胞外线如何塑造复杂的神经电路以实现可重复的大脑功能.

科学领域:

  • 神经科学是一个神经科学.
  • 发育生物学 发展生物学
  • 分子生物学分子生物学

背景情况:

  • 强大的树形态发生对于神经电路的发展至关重要,但细胞外模式的线索仍然不太了解.
  • *C. elegans*的PVD感觉神经元表现出一种刻板印象的,高度分支的树形态,作为研究树形状的模型.

研究的目的:

  • 识别和描述指导PVD树突的空间受限生长和分支的细胞外因素.
  • 阐明构成,稳定和组织复杂树树的分子机制.

主要方法:

  • 一个涉及膜粘附分子的三方联体受体复合物的识别.
  • 对影响*C. elegans*中确定的复合体的突变进行遗传分析.
  • 在体内和体外实验中评估复杂组件对树突模式的必要性和充分性.

主要成果:

  • 确定了一个由SAX-7/L1CAM,MNR-1 (连接体) 和DMA-1 (受体) 组成的三方复合体.
  • 这种复合体是必要的,也是足够的,以指导空间受限的PVD树生长和分支.
  • 复杂组件中的突变导致树树形成,稳定和组织的严重缺陷.
  • 宫外表达SAX-7和MNR-1会以DMA-1-依赖的方式诱导可预测的,异常的树突结构.

更多相关视频

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

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相关实验视频

Last Updated: May 7, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

9.5K
Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

14.7K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

6.4K

结论:

  • 这种SAX-7/L1CAM,MNR-1和DMA-1复合体作为PVD树形态发生的关键细胞外线线索.
  • 这三方相互作用是建立复杂和有组织的树突结构的基础.
  • 了解这种机制,可以了解神经电路发育的调节.