与中心体相关的初级纤毛膜的不对称遗传导致细胞分裂后的纤毛发生
Judith T M L Paridaen1, Michaela Wilsch-Bräuninger, Wieland B Huttner
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, 01307 Dresden, Germany.
Cell
|October 15, 2013
概括
主性纤毛膜被内细胞化,在细胞分裂过程中由一个子细胞不对称地继承. 这种遗传影响干细胞的特征和初级毛的重新建立,控制毛发生.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
- 器官生物学 有机生物学
背景情况:
- 主性乳毛是关键的感官器官.
- 乳毛通常在细胞分裂 (线粒分裂) 之前被拆解.
- 细胞分裂期间纤毛膜的命运以前是未知的.
研究的目的:
- 为了研究细胞分裂过程中纤毛膜的命运.
- 了解纤毛膜遗传在细胞命运决定中的作用.
主要方法:
- 在分裂胚胎新皮层干细胞和培养细胞中跟踪纤维膜.
- 观察细胞内分泌,线粒细胞持久性和纤毛膜的不对称遗传.
主要成果:
- 附着在母中心体的纤维膜在线粒分裂开始时被内细胞化.
- 内细胞化膜是不对称地由一个子细胞继承的.
- 继承的子细胞比其他子细胞更早地通过激活的信号传感器重新建立了初级.
- 纤毛膜的中心体关联性降低了神经干细胞的分化.
结论:
- 纤毛膜在细胞分裂过程中不对称地遗传.
- 纤毛膜的遗传影响干细胞特征和纤毛发生.
- 中心细胞关联的纤维膜在纤维生成的时空控制中发挥作用.
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