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Updated: May 7, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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质母细胞瘤的体内基因组景观

Cameron W Brennan1, Roel G W Verhaak, Aaron McKenna

  • 1Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA.

Cell
|October 15, 2013
PubMed
概括

这项研究全面描述了500多种质母细胞瘤瘤,确定了新的突变和复杂的重组. 研究结果揭示了质母细胞瘤亚型和治疗反应的生物标志物,进步了对这种致命癌症的理解.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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