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Updated: May 7, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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一个G蛋白结合受体由全药物调节的结构基础

Ron O Dror1, Hillary F Green, Celine Valant

  • 11] D. E. Shaw Research, 120 West 45th Street, 39th Floor, New York, New York 10036, USA [2].

Nature
|October 15, 2013
PubMed
概括

研究人员使用原子模拟确定了G蛋白结合受体 (GPCR) 基调节器的结合部位和机制. 这为设计针对GPCRs的新药提供了结构基础,比如M2肌肉酸乙胆受体.

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