美国捐赠卵细胞周期的趋势和结果,2000-2010年
Jennifer F Kawwass1, Michael Monsour, Sara Crawford
1Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia2Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA
|October 19, 2013
概括
在美国,从2000年到2010年,捐赠卵细胞周期的数量有所增加,并增加了良好的围产期结局. 像第五天胚胎移植和单个胚胎移植这样的因素提高了成功率.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 卵细胞捐赠 卵细胞捐赠
背景情况:
- 卵子捐赠用于试管婴儿在美国越来越普遍.
- 关于母亲和婴儿结局的数据有限,这阻碍了临床决策和咨询.
- 了解成功的趋势和预测因素对于改善患者护理至关重要.
研究的目的:
- 分析2000年至2010年美国捐赠卵细胞周期的趋势.
- 使用新鲜捐赠卵子在试管婴儿周期中确定成功产周结局的预测因素.
- 为卵细胞捐赠提供咨询和临床策略提供信息.
主要方法:
- 分析国家ART监控系统数据 (2000-2010年).
- 包括超过95%的美国试管婴儿周期的数据.
- 良好的周产期结果的定义是单独活产在≥37周和≥2500g时.
主要成果:
- 每年捐赠卵细胞周期从10801个增加到18306个 (2000-2010年).
- 良好的周产期结果从18.5%增加到24.4% (P<.001).
- 第五天的胚胎移植和选择性单个胚胎移植与更高的成功率有关;输卵管/子宫因子不孕症和非西班牙裔黑人种族与较低的成功率有关.
结论:
- 美国捐赠卵细胞周期和良好的产周期结果在2000-2010年间增加.
- 需要进一步的研究来阐明影响不太成功结果的因素.
- 这些发现支持对卵子捐赠计划的持续监测和研究的需要.
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