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轻度抗血素缺乏和复发静脉血栓栓塞的风险:一个前性队列研究

Matteo Nicola Dario Di Minno¹, Francesco Dentali, Roberta Lupoli

¹Department of Clinical Medicine and Surgery, Federico II University, Naples (M.N.D. Di M., R.L.); and Department of Clinical Medicine, University of Insubria, Varese (F.D., W.A.), Italy.

|October 23, 2013

概括

轻度抗血素缺乏 (70-80%) 在未引起的静脉血栓塞栓症患者中显著增加了复发性静脉血栓塞栓症 (VTE) 的风险. 这一发现对于确定二次预防策略的持续时间至关重要.

科学领域:

血液学血液学血液学
血栓形成研究研究

背景情况:

抗血素缺乏 (<70%) 是已知的静脉血栓塞栓症 (VTE) 的风险因素.
缺乏关于在轻度抗血缺乏症 (70-80%) 中复发性VTE风险的前性数据.

研究的目的:

为了研究患有不同水平的抗血素,特别是轻度缺乏症的患者中复发性静脉血病的风险.
为了评估抗血素水平与第一次VTE事件后VTE复发之间的关联.

主要方法:

预期跟踪823名患者,他们的第一次VTE事件平均为8.70年.
基于功能性抗血素水平的患者分层:<70%,70-80%,和>80%.
经VTE风险因素和抗凝固持续时间调整后的统计分析.

主要成果:

整体VTE复发率为每年3.53%的患者.
抗血素水平<70%的患者患有VTE复发的风险增加了3.48倍 (HR, 3.48;95% CI, 2.16-5.61).
与>80%水平相比,轻度抗素缺乏症患者 (70-80%) 的VTE复发风险增加了2.40倍 (HR,2.40;95% CI,1.51-3.80).
这种关联在未引起的VTE患者中是显著的.

结论:

轻度抗素缺乏 (70-80%) 与未引起的VTE患者复发VTE的风险显著增加有关.
在决定VTE二次预防的持续时间时,应考虑抗素水平.

关键词:

抗血素是一种抗血素.血栓塞栓症血栓塞栓症血栓塞栓症血栓友爱症 (Thrombophilia) 是一种发生血栓友爱的疾病.

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