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艾滋病毒逆转录酶的皮科莫拉抑制剂,其特征是诺维尼尔烯基组的双循环替代

Won-Gil Lee1, Ricardo Gallardo-Macias, Kathleen M Frey

  • 1Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.

Journal of the American Chemical Society
|October 25, 2013
PubMed
概括

研究人员设计了新的双循环化合物,以取代HIV-1逆转录酶抑制剂中的活性组. 这些新型非核酸抑制剂 (NNRTIs) 对野生型和耐药HIV-1菌株表现出强烈的活性.

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